A few clinical reports described a critical temporal relationship between vaccination and acute nephrotic syndrome, indirectly suggesting an association. For this review, the literature was reviewed to identify articles reporting associations of nephrotic syndrome with vaccines against a vast array of infectious diseases (including bacteria ...

2021年2月5日 · Background: Children with nephrotic syndrome (NS) are at high risk for vaccine-preventable infections due to the immunological effects from the disease and concurrent treatment with immunosuppressive medications. Immunizations in these patients may be deferred due to their immunosuppressive treatment which may increase the risk for vaccine ...

2021年2月4日 · Background: Children with nephrotic syndrome (NS) are at high risk for vaccine-preventable infections due to the immunological effects from the disease and concurrent treatment with immunosuppressive medications. Immunizations in these patients may be deferred due to their immunosuppressive treatment which may increase the risk for vaccine ...

Nephrotic children are at high risk for severe pneumococcal infections as one of the life-threatening complications of nephrotic syndrome due to involvement of the immunosuppressive regimen and the acquired immune deficiency induced by nephrotic syndrome including decreased plasma IgG and low complement system components.

2022年12月13日 · The use of vaccines in nephrotic syndrome (NS) is a timely topic, discussed over many years. Patients with NS are, in fact, at high risk of developing serious infectious complications based on immune-depression arising from hypogammaglobulinemia, urinary loss of complement factors, and immunosuppressive agents [ 1 , 2 ].

The specific treatment of idiopathic nephrotic syndrome is based on corticosteroid therapy and/or steroid-sparing immunosuppressive agents in children who are steroid-dependant or frequent relapsers (60-70 %). Patients have an increased infectious risk not only related to the disease during relapses …

Pathogenic mechanisms of nephrotic syndrome are still not fully elucidated, but increasing evidence points at a dysregulation of the immune system, involving both B and T cells. This also raises the intriguing hypothesis that vaccines, by eliciting an …

2021年11月3日 · Immunization is essential in preventing life-threatening pneumococcal infections in children with nephrotic syndrome. An additional 23-valent pneumococcal polysaccharide vaccine (PPSV23) series is required for children with nephrotic syndrome. Despite current practice guidelines, many children with nephrotic syndrome do not receive PPSV23.

2021年3月12日 · Idiopathic nephrotic syndrome (INS) is the most frequent glomerular disease in childhood. However, it has a rare incidence (1–17 cases per 100.000 children per year) ( 1 ). INS is characterized by a damage of the glomerular permeability barrier, which causes a severe leakage of proteins into the urine, associated with hypoalbuminemia and ...

20 小时之前 · Global evidence on the association between vaccines and renal adverse events (AEs) is inconclusive. This pharmacovigilance study analyzed a total of 120,715,116 reports from VigiBase collected ...