2024年12月24日 · ABCG1 (ATP Binding Cassette Subfamily G Member 1) is a Protein Coding gene. Diseases associated with ABCG1 include Hypoalphalipoproteinemia, Primary, 1 and …

ABCG1 redistributes cholesterol to cell-surface domains where it becomes accessible for removal by HDL, demonstrating its direct role of ABCG1 in cellular cholesterol transport; ABCG1 and …

2024年12月25日 · ABCG1 regulates pulmonary surfactant metabolism in mice and in humans. ABCG1-deficient mice have been shown to accumulate surfactant, lipid-laden macrophages …

2017年9月2日 · ATP-binding cassette G1 (ABCG1) is a member of the large family of ABC transporters which are involved in the active transport of many amphiphilic and lipophilic …

2015年2月27日 · ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of …

Currently, five members of the ABCG subfamily are known to exist in humans: ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. Fig. 1. Phylogenetic tree of all human ABC genes and …

As ABCG1 is a half transporter 8, dimerization is required for function 4. Whilst ABCG1 is generally considered to function as a homodimer 9, recent evidence suggests it also forms …

2022年1月25日 · The cryo-EM structure of human ABCG1 reported by Xu et al. reveals an ABCG1-driven cholesterol transport cycle initiated by sphingomyelin-assisted cholesterol …

Our data demonstrate that ABCG1 is an intracellular sterol transporter that localizes to endocytic vesicles to facilitate the redistribution of specific intracellular sterols away from the …

Overall, we propose an ABCG1-driven cholesterol transport cycle initiated by sphingomyelin-assisted cholesterol recruitment and accom-plished by the release of cholesterol to HDL.