Astrocytes generate abundant mitochondrial reactive oxygen species and shuttle to neurons glycolytically derived metabolites, such as L-lactate and L-serine, which sustain energy needs, …

2023年4月12日 · Identifying astrocyte and neuron proteomes is essential for elucidating the protein networks that dictate their respective contributions to physiology and disease. Here we …

2024年4月3日 · Through super-resolution microscopy, in vivo proximity labeling by secreted TurboID, and astrocyte-specific rescue approaches, we discovered that the synaptogenic …

2017年11月1日 · In this review, we summarize some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication, focusing on …

Astrocytes are the key component of the central nervous system (CNS), serving as pivotal regulators of neuronal synapse formation and maturation through their ability to dynamically …

Interactions between neurons and astrocytes are critical for signaling, energy metabolism, extracellular ion homeostasis, volume regulation, and neuroprotection in the central nervous …

2021年3月2日 · Here, we demonstrate that in the adult mouse brain, small molecules can reprogram astrocytes into neurons. The in situ chemically induced neurons resemble …

2024年12月1日 · Astrocytes communicate bidirectionally with neurons to control synapse assembly. NDD-linked genes converge on synapse development and transcriptional …

2023年2月1日 · In this review, we provide an overview and perspective of astrocyte–neuron contacts mediated by adhesion molecules in developing neural circuits and synapse formation, …

2021年8月1日 · Astrocytes directly contact axons and dendrites via cell adhesion molecules (CAMs). Transcellular contact controls synaptogenesis and astrocyte maturation concurrently. …