2023年2月13日 · Here, we report the cryo-EM structures of the EGFR/HER2 ectodomain complex with two EGFR ligands — epidermal growth factor (EGF) and epiregulin (EREG) — at resolutions of 3.3 Å and 4.5 Å,...

HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR.

2003年2月13日 · Here we report crystal structures of the entire extracellular regions of rat HER2 at 2.4 Å and human HER2 complexed with the Herceptin antigen-binding fragment (Fab) at 2.5 Å.

Structure of the HER2 and Neu proteins. The domain structure is shown on the left consisting of two ligand binding regions (LD1 & LD2), two cysteine-rich regions (CR1 & CR2), a short transmembrane domain (TM), a catalytic tyrosine kinase domain (TK), and a …

2023年2月25日 · HER家族有11种配体，配体从胞外选择性地与受体结合后，可诱导受体形成同源或者异源二聚体，进而激活胞内激酶结构域，开启下游信号通路，如RAS-MAPK和PI3K-AKT等。 HER家族蛋白在调控细胞增殖、分化、个体发育和组织动态平衡等生物学过程中发挥重要作用。 该家族成员的过表达或异常激活与多种癌症的发生高度相关，如肺癌、乳腺癌和胶质瘤等。...

Here, we report the cryo-EM structures of the EGFR/HER2 ectodomain complex with two EGFR ligands — epidermal growth factor (EGF) and epiregulin (EREG) — at resolutions of 3.3 Å and 4.5 Å, respectively. These two structures are almost identical and …

HER family comprises four members, namely HER1 (EGFR), HER2 (NEU), HER3, and HER4 with differential tissue expression patterns. All four members of the family share a common three-dimensional...

2002年11月21日 · Here we report crystal structures of the entire extracellular regions of rat HER2 at 2.4 A and human HER2 complexed with the Herceptin antigen-binding fragment (Fab) at 2.5 A. These structures reveal a fixed conformation for HER2 that resembles a ligand-activated state, and show HER2 poised to interact with other ErbB receptors in the absence ...

2021年11月10日 · Our structure of the HER2 (S310F)–HER3–NRG1β–trastuzumab Fab complex reveals that the receptor dimer undergoes a conformational change to accommodate trastuzumab. Thus, similar to oncogenic...

2014年3月20日 · Crystallographic analysis was used to determine the three-dimensional structure to 3.5 Å resolution, confirming that the epitope of this antibody is in domain III of HER2. Moreover, this novel anti-HER2 antibody exhibits superior efficacy in blocking HER2/HER3 heterodimerization and signaling, and its use in combination with pertuzumab has a ...