The half-lives of proteins within cells vary widely, from minutes to several days, and differential rates of protein degradation are an important aspect of cell regulation. Many rapidly degraded …

2022年4月4日 · Targeted protein degradation (TPD), via the proteasomal and lysosomal pathways, represent a novel tool to explore cellular pathways and a promising therapeutic …

Protein degradation occurs through a variety of cellular processes used to engulf extracellular proteins, including receptor-mediated endocytosis, pinocytosis, phagocytosis, and autophagy. …

2024年4月29日 · Two distinct classes of protein degradation therapeutics are being widely explored: bifunctional PROTACs and molecular glue degraders, both of which have their …

Protein degradation in living cells is a highly selective process in which damaged or misfolded proteins are readily targeted for destruction. However, this process extends far beyond the …

2024年1月5日 · One significant research topic in the world of protein is its degradation. Protein degradation is important for gene expression regulation, cell signaling, repair after exposure to …

5 天之前 · For example, the E3 ligase APC/C binds to D- or KEN-box degrons in proteins that regulate cell division to establish a sequence of protein-degradation events that orchestrates …

Most cellular proteins are selectively degraded by the proteasome via ubiquitination. Moreover, the ubiquitin–proteasome system is a critical process for maintaining protein homeostasis.

2022年4月21日 · Protein degradation occurs through proteasomal, endosomal, and lysosomal pathways. Technological advancements have allowed for the determination of protein copy …

2025年1月17日 · The nascent field of targeted protein degradation (TPD) could revolutionize biomedicine due to the ability of degrader molecules to selectively modulate disease-relevant …

Protein degradation is an essential cellular function that, when dysregulated or impaired, can lead to a wide variety of disease states. The two major intracellular protein degradation systems are …

2024年7月12日 · Explore the intricate processes of protein folding and degradation in cells, highlighting key mechanisms and pathways involved.

Proteins are targeted for proteasomal degradation by a two-part degron, which consists of a proteasome binding signal and a degradation initiation site. Here we describe how both …

Protein degradation is essential for protein homeostasis and cell survival because it replenishes the amino acid pool for de novo protein synthesis, allowing cells to adapt to their ever …

6 天之前 · Despite the critical role of ClpXP in mitochondrial protein quality control, the specific degrons, or modifications that tag substrate proteins for degradation by human ClpXP, are still …

2023年12月6日 · Protein degradation is a natural process by which cells break down proteins that are damaged or no longer needed so they can be recycled or disposed of. Scientists at Dana …

Scientists are leveraging the body's natural protein degradation system to target and remove proteins influencing disease processes for therapeutic purposes.

2024年12月24日 · Enabling protein degradation with small-molecule drugs has emerged as an innovative approach to the development of therapeutics against otherwise intractable targets.

Much like how ubiquitin tags proteins for degradation in the cytosolic ubiquitin–proteasome system, our study reveals that phosphorylation of serine residues serves as a key signal for …

Targeted protein degradation (TPD), via the proteasomal and lysosomal pathways, represent a novel tool to explore cellular pathways and a promising therapeutic approach. 29 The concept …

Our scientists are leveraging three different modalities of targeted protein degradation – molecular glues, also called CELMoD TM agents, ligand-directed degraders (LDDs) and antibody drug …

2022年4月21日 · Protein degradation occurs through proteasomal, endosomal, and lysosomal pathways. Technological advancements have allowed for the determination of protein copy …

Protein degradation is crucial for maintaining cellular function for several reasons. First, it regulates protein levels within the cell, ensuring that proteins are available in the right amounts …

5 天之前 · A recent “Nature” paper by the groups of Jacob Corn (IMHS, D-BIOL) and Jeffrey Bode (D-CHAB) reveals how cells remove chemically damaged proteins. They discovered that the …

Degradation destined proteins are degraded via distinct pathways. For example, a newly synthesized, yet misfolded protein is degraded via the UPS or ERAD pathways in ubiquitin …