Priming (immunology) - Wikipedia
T and B cell priming occurs in the secondary lymphoid organs (lymph nodes and spleen). Priming of naïve T cells requires dendritic cell antigen presentation. Priming of naive CD8 T cells …
The Timing of T Cell Priming and Cycling - PMC - PubMed …
The first approach to do this was to prime naive CD4 + T cells in plates coated with peptide/MHC complexes and transfer the cells to uncoated wells at different times, with the effects of …
T cell priming goes through a new phase | Nature Immunology
2013年3月19日 · The priming of naive T cells requires antigen presentation by activated dendritic cells, yet the optimal generation of effector and memory CD8 + T cells requires subsequent T …
T-cell priming by dendritic cells in lymph nodes occurs in three ...
2004年1月8日 · The three-stage time course of T-cell priming by DCs documented here provides a roadmap for testing these concepts and the underlying mechanisms in situ.
T cell priming: let there be light | Cell Research - Nature
2010年5月25日 · Activation of naïve T cells via the T cell receptor (TCR) induces proliferation, gain of effector functions, and ultimately the development of long-lived memory cells.
CD4 + T Cell Priming as Biomarker to Study Immune Response to ...
CD4 + T cell priming, required for the induction of high-affinity antibodies and immune memory, represents a key target for improving and modulating vaccine immunogenicity. A major …
Architects of immunity: How dendritic cells shape CD8 + T cell
2025年1月17日 · Immune responses against cancer are dominated by T cell exhaustion and dysfunction. Recent advances have underscored the critical role of early priming interactions …
LFA-1 in T cell priming, differentiation, and effector functions
2021年7月12日 · LFA-1 participates in homotypic T cell–T cell interactions that drive Th1 differentiation responses and the formation of T cell memory. LFA-1 signals license human T …
Role of mouse dendritic cell subsets in priming naive CD4 T cells
In this review, we focus on the role of mouse cDC subsets in priming (i.e., early activation and proliferation) of naive CD4T cells in vivo. The kinetics of CD4T cell priming is best studied in …
T-cell priming by type-1and type-2 polarized dendritic cells: the ...
1999年12月1日 · Primary immune responses are initiated by dendritic cells (DCs), which inform naive T helper (Th) cells about invading pathogens, providing an antigen-specific ‘signal 1’ and …