The mTOR pathway is a central regulator of mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose …

2020年3月9日 · There are 4 main functions of the mTOR signaling pathway: cell growth and proliferation, angiogenesis, bioenergetics through nutrient availability and boosting of …

Pathway Description: The mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that is present in two distinct complexes. The first, mTOR complex 1 (mTORC1), is …

2024年1月12日 · The mTOR signaling pathway, which is frequently activated in tumors, is crucial for tumor metabolism because it not only controls protein synthesis and gene transcription to …

2020年3月10日 · Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body. Studies have shown …

2009年10月15日 · The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, …

In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported …

The mTOR signaling pathway is a critical regulator of cellular processes, with wide-reaching implications in health and disease. Understanding its complex regulatory mechanisms opens …

The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 …

The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory …