Defining ‘T cell exhaustion’ | Nature Reviews Immunology
2019年9月30日 · In this Viewpoint article, 18 experts in the field tell us what exhaustion means to them, ranging from complete lack of effector function to altered functionality to prevent …
CD8 + T cell exhaustion - PubMed
In the case of chronic infection or cancer, CD8 + T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8 + T cells to gradual …
Hallmarks of CD8+ T cell dysfunction are established within hours …
2023年8月3日 · Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, also known as exhaustion, is thought to …
In vitro modeling of CD8 + T cell exhaustion enables CRISPR …
2023年8月18日 · T cell exhaustion is a distinct cell state that arises during chronic viral infection and cancer. Exhausted CD8 T cells (T ex) are defined by reduced proliferative potential, high …
Subsets of exhausted CD8 + T cells differentially mediate ... - Nature
2019年2月18日 · Here we show that such therapy acts on a specific subpopulation of exhausted CD8 + tumor-infiltrating lymphocytes (TILs). Dysfunctional CD8 + TILs possess canonical …
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
2019年4月26日 · Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by …
CD8 + T cell exhaustion in anti-tumour immunity: The new
This review just focuses our current understanding of the biology of exhausted CD8 + T cells, including differentiation pathways, cellular characteristics and signalling pathways involved in …
Architects of immunity: How dendritic cells shape CD8+ T cell …
2025年1月17日 · CD8 + T cell exhaustion, often associated with failed tumor control, was first defined in chronic viral infections (3, 4).Exhaustion represents a distinct epigenetic and …
Regulatory Mechanisms and Reversal of CD8 + T Cell Exhaustion: …
2023年4月1日 · CD8 + T cell exhaustion is a state of T cell dysfunction during chronic infection and tumor progression. Exhausted CD8 + T cells are characterized by low effector function, …
CD8 + T Cell Exhaustion in Cancer - PubMed Central (PMC)
CD8 + T cell functionality (the ability to rapidly expand after priming, produce effector cytokines and cytolytic molecules, and contract to form memory) characterizes acute recognition of …