Candida biofilms occur mostly in the mucosa or endothelium being involved in the development of common candidiasis, such as vaginal and oral candidiasis, but also associated with medical devices, such as vascular and urinary catheters and dentures .

A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, ...

The formation of Candida biofilms carries important clinical repercussions because of their increased resistance to antifungal therapy and the ability of cells within biofilms to withstand host immune defenses.

In this review, we highlight host-biofilm interactions for Candida, focusing on how biofilm formation influences innate immune responses. Candida spp. are the primary cause of nosocomial fungal infections and recently rose to the leading pathogen group causing nosocomial bloodstream infections (Magill et al., 2014).

2016年5月1日 · In this review, we focus on Candida albicans biofilms, which can colonize mucosal surfaces, such as those coating the oral and vaginal epithelia, and implanted medical devices, such as prosthetics, heart valves, and catheters, and can seed systemic infections in humans (see Fig. 1 for common C. albicans biofilm-associated infections occurring ...

In this chapter, we will focus on Candida biofilms (biofilms caused by Aspergillus are covered in reference 155) and provide an update on their development, architecture, and resistance mechanisms.

Candida albicans is highly adaptable, enabling the transition from commensal to pathogen due to a repertoire of virulence factors. Specifically, the ability to change morphology and form biofilms is central to the pathogenesis of C. albicans.

2022年11月1日 · Candida albicans is a fungal pathogen that can form biofilms on medical devices and host tissue, resulting in serious, life-threatening infections. These fungal biofilms are inherently resistant to traditional antifungal therapies and the host immune system; therefore, biofilm-associated infections are a huge clinical challenge.

2023年3月18日 · Candida biofilms are important in superficial and deep infections. The mucosal barriers of the oral cavity, oropharynx, respiratory, gastrointestinal, and genitourinary tracts are all potential sites for the genus Candida to reside, colonize and potentially initiate pathogenesis.

2024年8月24日 · Candida biofilms are complex, protective structures formed by Candida species, particularly Candida albicans. These biofilms are made up of dense microbial communities encased in a polysaccharide matrix, which acts as a shield against external threats, including antifungal treatments and the immune system.

A variety of biomaterials used in clinical practice are able to support biofilm formation by Candida and, ironically, the increase in candidiasis in recent years (now the third to fourth most common nosocomial infection in US hospitals and abroad) has been virtually concomitant with the increase in use of a broad range of medical implant ...

The formation of Candida biofilms has been observed on multiple surfaces, including living surfaces (mucous membranes, organs, blood vessels) and non-living surfaces, most often in the case of medical devices that come into contact with patients’ bodies (stents, shunts, implants, endotracheal tubes, pacemakers, and multiple types of catheters ...

2025年2月1日 · Dose-dependent analysisc to clarify the effect of C. albicans supernatant on P. aeruginosa biofilm formation. Mixed infections of C. albicans and P. aeruginosa typically manifest as biofilms. We compared the effects of C. albicans supernatant on P. aeruginosa wild-type strain PAO1 and defective strains ΔlasIrhlI and ΔlasRrhlR using crystal violet semi-quantification and determined the colony ...

In this brief review, we provide an update of the processes involved in biofilm formation by Candida spp. (formation, treatment, and control), as well as the transcriptional circuitry that regulates its development and interactions with other microorganisms.

In this review, we highlight key host interactions with Candida biofilms, describing how the host responds differently to Candida during biofilm and non-biofilm growth (Figure 1).

5 天之前 · Biofilm tolerance to antifungals is a multifactorial process that involves conserved and unique (and possibly still undiscovered) mechanisms across the four priority fungal pathogens: Candida ...

4 天之前 · This study reveals that one of the ways carvacrol inhibits hyphal and biofilm formation in Candida albicans is by blocking amino acid uptake. The repression of ARO1 eliminates co-enzyme Q precursors, resulting in mitochondrial respiratory and metabolic dysfunction, therefore disrupting hyphal growth and biofilm maturation.

Pathogenic fungi in the genus Candida can cause both superficial and serious systemic disease, and are now recognized as major agents of hospital-acquired infection. Many Candida infections involve the formation of biofilms on implanted devices such as …

In this article, we will focus on fungal biofilms (mainly Candida biofilms) and provide an update on the development, architecture, and resistance mechanisms of biofilms.

2023年1月1日 · Species of Candida, namely Candida tropicalis, Candida albicans, Candida glabrata, C. parapsilosis, etc., are known to form biofilm. Various factors that affect the virulence factor of pathogenic yeast are biofilm formation, adhesion, filamentation, and extracellular polymeric substances production.

Once it forms on an implanted medical device, a Candida biofilm has the potential to seed disseminated bloodstream infections and to lead to invasive systemic infections of tissues and organs.

5 天之前 · Urogenital infections impact millions of individuals globally each year, with vulvovaginal candidiasis (VVC) being one of the most prevalent conditions affecting women. Candida albicans is the primary pathogen responsible for VVC. The utilization of probiotics as an alternative therapeutic approach to antibiotics in managing such infections has gained increasing attention. This study aimed to ...

2020年6月25日 · Cells that disperse from biofilms display a phenotype of enhanced pathogenicity. In this review, we highlight host-biofilm interactions for Candida, focusing on how biofilm formation influences innate immune responses.

Like other microorganisms, free-living Candida albicans is mainly present in a three-dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form. Candida albicans biofilms can be isolated from both abiotic and biotic surfaces at various locations within the host.

2025年2月4日 · Biofilm is a community of bacteria formed on various surfaces, consisting of both viable and dead bacterial cells. ... Similarly, several yeast species, such as Candida glabrata, Yarrowia lipolytica, and Pichia jadinii, have been employed in nanoparticle synthesis . The remarkable properties of biosurfactants, along with their ability to act as ...