Cathepsin B - Wikipedia
Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis. [5] In humans, cathepsin B is encoded by the CTSB gene. [6] [7] Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions. [8] [9 ...
Cathepsin B in programmed cell death machinery: mechanisms of …
2023年4月8日 · Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal and lysosomal compartments. It is involved in the turnover of intracellular and extracellular...
Cathepsin B: Multiple roles in cancer - PMC - PubMed Central (PMC)
Proteases, including intracellular proteases, play roles at many different stages of malignant progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of cathepsin B are found in a wide variety of human cancers, ...
Cathepsin B as a Cancer Target - PMC - PubMed Central (PMC)
Studies have shown that abnormal regulation of cathepsin B causes cells to acquire an oncogenic character. Cathepsin B is normally associated with the lysosomes involved in autophagy and immune response, but its aberrant expression has been shown to lead to cancers.
The Role of Cathepsin B in Pathophysiologies of Non-tumor and …
Cathepsin B (CTSB), a lysosomal cysteine protease, plays an important role in human physiology and pathology. CTSB is associated with various human diseases, and its expression level and activity are closely related to disease progression and severity.
Cathepsin B - an overview | ScienceDirect Topics
Cathepsin-B is a lysosomal cysteine protease. During physical exercise, it is released from skeletal muscle cells. Cathepsin-B was found to pass through the blood–brain barrier and induce an increase in brain levels of BDNF. This was associated …
Cathepsin B: structure, function, tumorigenesis, and prognostic …
2022年1月1日 · Active cathepsin B is mainly found in endosomal/lysosomal compartment under the normal physiological conditions. The primary role for cathepsin B is bulk turnover of intracellular and extracellular proteins, maintaining intracellular homeostasis.
Cathepsin B: multiple roles in cancer - PubMed
Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of cathepsin B are found in a wide variety of human cancers, levels that often induce secretion and association of cathepsin B with the tumor cell membrane.
Behind every smile there's teeth: Cathepsin B's function in …
2022年4月1日 · Cathepsin B (CatB) is a very abundant lysosomal protease with endo- and carboxydipeptidase activities and even ligase features. In this review, we will provide a general characterization of CatB and describe structure, structure-derived properties and location-dependent proteolytic actions.
Distinct Cleavage Properties of Cathepsin B Compared to Cysteine ...
2023年7月17日 · Activated microglia are the main cellular source of interleukin-1β in the brain. Cathepsin B is associated with the production and secretion of interleukin-1β through pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the phagolysosomes.