Epidermal growth factor receptor - Wikipedia
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
Biochemistry, Epidermal Growth Factor Receptor - StatPearls
2023年12月3日 · The epidermal growth factor receptor (EGFR) family is a subclass of receptor tyrosine kinase (RTK) proteins and consists of 4 members: EGFR (ErbB1, HER1), ErbB2 (HER2, neu in rodents), ErbB3 (HER3) and ErbB4 (HER4).
EGFR protein expression summary - The Human Protein Atlas
EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer.
EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired …
Once activated by a ligand, EGFR initiates a time-dependent series of molecular switches comprising downregulation of a large cohort of microRNAs, up-regulation of newly synthesized mRNAs, and covalent protein modifications, collectively controlling phenotype-determining genes.
Epidermal growth factor - Wikipedia
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-k Da [5] and has 53 amino acid residues and three intramolecular disulfide bonds. [6] EGF was originally described as a secreted peptide found in the submaxillary glands of mice and in human urine.
Epidermal Growth Factor Receptor Cell Proliferation Signaling …
We focus on the induction of CYCLIN D expression, CDK4/6 activation, and the repression of cyclin-dependent kinase inhibitor proteins (CDKi) by EGFR signaling pathways. We also discuss the successes and challenges of EGFR-targeted therapies, and the potential for their use in combination with CDK4/6 inhibitors.
EGFR Gene - GeneCards | EGFR Protein | EGFR Antibody
2024年12月24日 · EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer.
Structure and Dynamics of the EGF Receptor as Revealed by …
EGF is a polypeptide isolated in the late 1950s from the mouse submaxillary salivary gland that enhances epidermal growth and keratinization (reviewed in [1]). A single pass 170 KDa transmembrane glycoprotein, the EGFR was the first cell surface receptor to be found to exhibit tyrosine kinase activity [2].
EGFR epidermal growth factor receptor [ Homo sapiens (human) ]
2025年1月5日 · EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer.
1956 - Gene ResultEGFR epidermal growth factor receptor
This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer.