2019年7月16日 · Glucagon secreted from pancreatic alpha cells in the islet of Langerhans plays an important role in maintaining glucose homeostasis by stimulating hepatic glucose production (1). Thus, in contrast to the glucose-depositing nature of insulin action, glucagon acts as a glucose-mobilizing hormone.

Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It raises the concentration of glucose and fatty acids in the bloodstream and is considered to be the main catabolic hormone of the body. [1] It is also used as a medication to treat a …

2024年2月28日 · Mechanism of Action. Glucagon binds G-coupled surface receptors found throughout the body in varying concentrations, binding to the glucagon receptors in the liver, GI tract, heart, pancreas, fat, adrenal glands, and kidneys to activate adenylate cyclase, which raises cAMP levels. cAMP stimulates glycogenolysis and glucogenesis, resulting in ...

2023年3月6日 · Glucagon modulates glucose-6-phosphatase activity via the PKA-dependent mechanism. In addition to promoting glycogenolysis, glucagon also inhibits glycogenesis in the liver at the same time. Glycogen synthase is a significant …

2025年1月21日 · Glucagon helps blood glucose levels rise in multiple ways: Glucagon triggers your liver to convert stored glucose into a usable form. Your liver then releases it into your bloodstream. Glucagon can prevent your liver from taking in and storing glucose so that more glucose stays in your blood.

2005年6月13日 · Mechanism of action. Glucagon binds to the glucagon receptor activating G s α and G q. 1 This activation activates adenylate cyclase, which increases intracellular cyclic AMP and activates protein kinase A. 1 Activating G q activates phospholipase C, increases production of inositol 1,4,5-triphosphate, and releases intracellular calcium. 1 ...

2024年2月8日 · Mechanism of Action Glucagon binds to a specific glucagon receptor in the cell membrane, a G-protein coupled receptor (GPCR). This activates the enzyme adenylate cyclase which increases cAMP intracellularly.

Glucagon, a hormone secreted by pancreatic alpha cells, contributes to the maintenance of normal blood glucose concentration by inducing hepatic glucose production in response to declining blood glucose. However, glucagon hypersecretion contributes to the pathogenesis of type 2 diabetes.

In this article, we summarize the multifaceted nature of glucagon with a special focus on its hepatic action and discuss the pharmacological potential of either agonizing or antagonizing the glucagon receptor for health and disease.

Glucagon is a first-line therapy in treatment of β-blocker toxicity. Glucagon works by stimulating increases in intracellular cyclic adenosine monophosphate, independent of the β-receptors.