Glucagon-like peptide-1 receptor - Wikipedia
The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion.
Glucagon-Like Peptide-1 Receptor Agonists - StatPearls - NCBI …
2024年2月29日 · GLP-1 agonists (also known as GLP-1 receptor agonists, incretin mimetics, or GLP-1 analogs) represent a class of medications used to treat T2DM and, in some cases, obesity. Examples of drugs in this class include Exenatide, Liraglutide, Dulaglutide, and Semaglutide.
Glucagon-like peptide-1 receptor: mechanisms and advances in …
2024年9月18日 · The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various...
Glucagon-like peptide 1 (GLP-1) - PMC - PubMed Central (PMC)
The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of rodent β-cell proliferation.
The structure and function of the glucagon-like peptide-1 receptor …
GLP-1 is clearly an important hormone linking nutrient consumption with blood sugar control, and therefore knowledge of its structure, function and mechanism of action is of great importance. This article is part of a themed section on Secretin Family (Class B) G Protein-Coupled Receptors.
Glucagon-like peptide-1 receptor: Current Biology - Cell Press
2024年12月2日 · Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from the intestine that regulates glucose metabolism by stimulating insulin release, inhibiting glucagon secretion, and suppressing gastric motility.
Compare and Contrast the Glucagon-Like Peptide-1 Receptor …
2024年2月25日 · Glucagon-like peptide-1 receptor agonists (GLP-1RA, GLP-1DAs, incretin mimetics, or GLP-1 analogs) are a class of medications utilized in treating type 2 diabetes and obesity. Clinical trials show the superiority of GLP-1RA to other antihyperglycemic drugs in improving glycemic efficacy, reducing weight and blood pressure, and having a ...
How glucagon-like peptide 1 receptor agonists work - PMC
In recent years, glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become central in the treatment of type 2 diabetes (T2D). In addition to their glucose-lowering properties with low risk of hypoglycaemia, GLP-1RAs reduce body weight and ...
Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors…
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three major tissues in humans, enteroendocrine L cells in the distal intestine, α cells in the pancreas, and the central nervous syste …
Glucagon Like Peptide 1 Receptor - an overview - ScienceDirect
The glucagon-like peptide-1 receptor (GLP-1R) is a significant therapeutic target for small molecule drug discovery given the therapeutic impact of peptide agonists in the diabetes sphere.