2023年5月23日 · Continuous hypoxia extended median lifespan of Ercc1 Δ/-mice by 50% (23.6 weeks versus 15.7 weeks, Mantel–Cox P < 0.0001, n = 20 in hypoxia; n = 26 in normoxia) and maximum lifespan from 25.6 to 31.4 weeks (Wang–Allison P < 0.01).

2016年10月31日 · Here we report that, in mice, gradual exposure to severe systemic hypoxaemia, in which inspired oxygen is gradually decreased by 1% and maintained at 7% for 2 weeks, results in inhibition of...

2023年2月17日 · Hypoxemia in both adult male and female mice caused a small increase in the proliferation of right ventricular (RV) cardiomyocytes but had no effect on left ventricular (LV) myocyte proliferation. The increase in cardiac myocyte size (myocyte hypertrophy) was sufficient to account for the increase in heart size (cardiac hypertrophy).

2025年2月5日 · These findings suggest that high-altitude hypoxia exacerbates anxiety-like behavior in mice after TBI, with the severity of anxiety increasing incrementally as altitude rises.

Continuous hypoxia extended median lifespan of Ercc1 Δ/-mice by 50% (23.6 weeks versus 15.7 weeks, Mantel–Cox P < 0.0001, n = 20 in hypoxia; n = 26 in normoxia) and maximum lifespan from 25.6 to 31.4 weeks (Wang–Allison P < 0.01).

2023年3月28日 · Male C57BL/6J mice were exposed to hypobaric hypoxia at a simulated altitude of 7000 m for 1, 3, and 7 days (1HH, 3HH and 7HH respectively). The behavior of the mice was evaluated by novel object recognition (NOR) and morris water maze test (MWM), then, the pathological changes of mice brain tissues were observed by H&E and Nissl staining.

2023年6月8日 · Chronic limitation of oxygen (hypoxia) prevents replicative senescence in cultured cells and extends lifespan in yeast, worms and flies. Rogers et al. now provide evidence that hypoxia is also...

Using lean mice exposed to long-term IH and a cohort of lean OSA patients (n = 71), we conducted comprehensive hepatic transcriptomics, lipidomics, and targeted serum proteomics. Significantly, we demonstrated that long-term IH alone can induce NASH molecular signatures found in human steatohepatitis transcriptomic data.

2021年9月13日 · Pulmonary arteries of hypoxic mice exhibited an increased material stiffness that was likely due to collagen remodeling rather than excessive deposition (fibrosis), a change in smooth muscle cell phenotype reflected by decreased contractility and altered orientation aligning these cells in the same direction as the remodeled collagen fibers, end...

2017年1月12日 · Here we report that, in mice, gradual exposure to severe systemic hypoxaemia, in which inspired oxygen is gradually decreased by 1% and maintained at 7% for 2 weeks, results in inhibition of oxidative metabolism, decreased reactive oxygen species production and oxidative DNA damage, and reactivation of cardiomyocyte mitosis.