2024年4月29日 · Imidazole - cas 288-32-4, synthesis, structure, density, melting point, boiling point

Imidazole (ImH) is an organic compound with the formula (CH) 3 (NH)N. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. It can be classified as a heterocycle , specifically as a diazole .

IDENTIFICATION AND USE: Imidazole, an organic alkaloid, is an important pharmacophore in drug discovery. Imidazole is used as a Karl Fischer reagent in analytical chemistry and a reagent in synthetic organic chemistry.

2023年1月23日 · Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction of glyoxal and formaldehyde in ammonia, initially called glyoxaline. The current literature provides much information about the synthesis, functionalization, physicochemical characteristics and biological role of imidazole.

The rapid expansion of imidazole-based medicinal chemistry suggests the promising and potential therapeutic values of imidazole-derived compounds for treating incurable diseases.

Imidazole is used to treat cutaneous fungal infection, including candidiasis, dermatomycoses, pityriasis versicolor, and vaginal candidiasis. It acts by inhibiting 14-sterol-demethylase.

imidazole, any of a class of organic compounds of the heterocyclic series characterized by a ring structure composed of three carbon atoms and two nitrogen atoms at nonadjacent positions. The simplest member of the imidazole family is imidazole itself, a …

2021年7月29日 · The rapid expansion of imidazole-based medicinal chemistry suggests the promising and potential therapeutic values of imidazole-derived compounds for treating incurable diseases.

Structure of the histidine complex [Ni(κ 3-histidinate) 2] 2-. [1]A transition metal imidazole complex is a coordination complex that has one or more imidazole ligands.Complexes of imidazole itself are of little practical importance. In contrast, imidazole derivatives, especially histidine, are pervasive ligands in biology where they bind metal cofactors.

2024年4月22日 · The imidazole system can act both as a base and as an acid. Free imidazole is a moderately strong organic base (pK a 7.0). It can also act as a weak acid (pK a 14.5). Both the cation and the anion have symmetrical delocalized structures.