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    Cleveland Clinic
    https://my.clevelandclinic.org › health › body

    Gonadotropin-Releasing Hormone (GnRH): Purpose & Testing

    GnRH – Endometriosis.org

    All the GnRH agonists work in exactly the same way. When used continuously for periods of longer than 2 weeks, they stop the production of oestrogen by a series of mechanisms. This deprives the endometrial implants of oestrogen, causing them to become inactive and degenerate. Most women will stop bleeding within 2 months of starting treatment. Howe...

    Endometriosis.org

    GnRH agonist At present, the usual length of treatment with a GnRH agonist is 3–6 months. However, in Germany, 12 months treatment with add-back therapy (5 mg of norethisterone per day) has been approved, and other countries may do the same in the future. A 3 month course of treatment may relieve pain symptoms as effectively as a 6 month course , b...

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    Menopausal-type symptoms The side effects of the GnRH agonists are largely the result of the low levels of oestrogen in the body, so they are usually confined to the symptoms associated with the menopause. Side effects are common, and most women will experience at least one or two. The severity of the side effects varies from mild to severe, and so...

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    All the GnRH agonists work in the same way, so they are equally effective in regressing endometrial implants and reducing pelvic pain symptoms . They appear to be at least as effective as progestins in relieving pain . Use before surgery GnRH agonists should not be used before surgery to reduce the extent of peritoneal (superficial implants) diseas...

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    The GnRH agonists — like all the hormonal treatments for endometriosis — do not improve your chances of conceiving, without any reproductive techniques, so they should not be used as a treatment for infertility.

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