Langerhans Cell Histiocytosis - Cleveland Clinic
2023年12月26日 · Langerhans cell histiocytosis is a rare disorder that occurs when a type of immune system cell called Langerhans cells build up in your child’s body. When these cells accumulate, it can cause tissue damage and tumors to form.
Langerhans Cell Histiocytosis - StatPearls - NCBI Bookshelf
2024年4月18日 · Langerhans cell histiocytosis (LCH) is a neoplastic disorder that arises from an expansion of early myeloid cells in the bone marrow compartment, most commonly due to a clonal mutation in the RAS/MAP Kinase signaling pathway.
Langerhans cell histiocytosis - Wikipedia
Langerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Symptoms range from isolated bone lesions to multisystem disease. [1]
Langerhans Cell Histiocytosis (LCH): Symptoms, Causes, Treatment - WebMD
2023年9月21日 · One of these rare disorders -- which resembles some types of cancer -- is called Langerhans cell histiocytosis, or LCH. It most commonly appears in toddlers and very young children, but you can...
Langerhans Cell Histiocytosis Treatment - NCI - National Cancer Institute
2024年6月6日 · Langerhans Cell Histiocytosis (LCH) treatment depends on where it is found in the body and whether the LCH is low or high risk. Treatment can include chemotherapy, surgery, radiation therapy, photodynamic therapy, immunotherapy, and targeted therapy. Learn more in this expert-reviewed summary.
Langerhans cell histiocytosis | About the Disease | GARD
A rare systemic disease characterized by the accumulation (usually organized in granulomas) of macrophage, bearing the features of Langerhans cells in various tissues. Summary Read More
Langerhans cell histiocytosis | Blood - American Society of …
2020年4月16日 · Langerhans cell histiocytosis (LCH) is caused by clonal expansion of myeloid precursors that differentiate into CD1a + /CD207 + cells in lesions that leads to a spectrum of organ involvement and dysfunction. The pathogenic cells are defined by constitutive activation of the MAPK signaling pathway.
Langerhans Cell Histiocytosis (LCH): Guidelines for Diagnosis, …
Langerhans cell histiocytosis (LCH) is a heterogeneous disease, characterized by accumulation of dendritic cells with features similar to epidermal Langerhans cells in various organs. Any organ or system of the human body can be affected, but those more frequently involved are the skeleton (80% of cases), the skin (33%), and the pituitary (25%).
Langerhans cell histiocytosis - MedlinePlus
Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow.
Langerhans Cell Histiocytosis - Symptoms, Causes, Treatment
2024年12月18日 · Langerhans cell histiocytosis (LCH) is a rare disorder in children or adults that can affect the skin (macular, papular, ulcerative, or seborrheic rashes), bones (painful lytic lesions), lymph nodes, brain (pituitary, cerebrum and …