HDAC inhibition reduced the cleaved caspases 3, 6, 9, PARP and TUNEL positive ESCs, which were abrogated with MG132 (0.5 μmol/L), a specific proteasome inhibitor. Furthermore, HDAC …

Accordingly, we found that the proteasome inhibitor MG132 blocked KRAS suppression-induced loss of MYC protein (Figure 2D), and this was associated with accumulation of …

MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC 50 of 3 μM and prevents β-secretase cleavage. There are several …

2025年1月28日 · Embryos treated with drugs were immediately subjected to RfTAC-seq. For drug treatment of mouse ESC, CHX (20 μg/L) or MG132 (10 μM) were added into culture medium …

2011年11月23日 · Proteosome inhibitor MG132 and lentiviruses enabling inducible expression or knockdown of c-myb were used to regulate c-Myb in WT and knockout EB.

MG132 upregulates E-cadherin expression levels via the upregulation of ESE3. The results of the present study indicated that treatment with MG132 was associated with increased expression …

In this review, we aim to summarize available evidence on PIs pharmacology and underlying molecular-cellular mechanisms leading to PI-related cardiotoxicity. We also outline strategies …

2015年4月1日 · We demonstrate that acute combinatorial treatment with the proteasome inhibitor MG101 or MG132 and the HDAC inhibitor valproic acid (VPA) increases gene expression of …

2023年9月1日 · MG132 treatment significantly increased the levels of the p62 protein as well as the NRF1 protein, supporting our findings showing that NRF1 mediated the expression of the …

2005年10月1日 · In this study, we cloned mice from ES cells by a post-electrofusion MG132 treatment and improved development of cloned embryos with a sequential cultivation protocol.