Nigericin - Wikipedia
Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Its isolation from soil from Nigeria was described in the 1950s, by R.L Harned (et. al), [1] [2] and in 1968 the structure could be elucidated by X-ray crystallography. [3] The structure and properties of nigericin are similar to the antibiotic monensin.
Nigericin | Microbial toxin | NLRP3 Inflammasome Inducer ...
Nigericin is a microbial toxin derived from Streptomyces hygroscopicus. Nigericin acts as a potassium ionophore. The release of IL-1beta in response to nigericin has been demonstrated to be NALP3-dependent.
Nigericin - an overview | ScienceDirect Topics
Nigericin (C 40 H 67 O 11) is an antibiotic, which derives from the Streptomyces peucetius. As a polyether ionophore, nigericin has been widely used in veterinary medicine as a ruminant non-hormonal growth promoter as well as coccidiostatic agents in livestock and poultry breeding [1–4].
Nigericin | C40H68O11 | CID 34230 - PubChem
Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. It has a role as an antimicrobial agent, an antibacterial agent, a potassium ionophore and a bacterial metabolite.
Nigericin Boosts Anti-Tumor Immune Response via Inducing ...
Although nigericin was proven to be a promising anti-tumor agent in multiple cancers [19,20,21,22], the anti-cancer mechanisms of nigericin were not fully understood. Here, we first demonstrated that nigericin inhibited TNBC cell viability …
Nigericin attenuates lipopolysaccharides induced sepsis and ...
2023年8月1日 · Nigericin is a potent antibiotic derived from Streptomyces hygroscopicus which acts as a polyether ionophore. The anticancer property of nigericin was extensively studied, and it has been proven to inhibit cancer cell proliferation, progression, and invasion in prostate, colorectal, nasopharyngeal, and lung cancer.
Nigericin: Uses, Interactions, Mechanism of Action | DrugBank ...
2018年6月12日 · Nigericin may increase the neuromuscular blocking activities of Cisatracurium. Cocaine The risk or severity of methemoglobinemia can be increased when Nigericin is combined with Cocaine.