2024年4月16日 · The short answer to whether or not there are better options out there is: It depends. Antihistamines — such as Zyrtec, Claritin, and Allegra — work quickly and can usually be taken safely long term. Nasal steroid sprays are …

Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”). Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood-brain barrier.

2022年6月14日 · Allergists recommend long-acting, non-sedating antihistamines — ones that won’t make you sleepy — for everyday use. Though you may know them by their brand names, the generic versions tackle the same problems: Cetirizine (Zyrtec®, Aller-Tec®, Wall-Zyr®). Fexofenadine (Allegra®, Aller-ease®, Aller-Fex®, Wal-Fex®).

2024年4月16日 · What are the best non-drowsy antihistamines? If you’re looking for allergy relief without the drowsiness, your best options are second- or third-generation antihistamines (more details on these terms later). They’re available over the counter (OTC) or with a prescription. Examples include:

2000年10月15日 · Mann and colleagues analyzed side effect data on four second-generation antihistamines to assess the frequency of sedation in patients taking these agents.

2023年4月17日 · Second generation (non-sedating) antihistamines were developed in the 1980s and are much less sedating than first-generation antihistamines. They act on histamine-1 receptors in the periphery and are unlikely to penetrate the brain, so are less likely to cause side effects or interact with drugs.

2020年11月3日 · The non-sedating antihistamines include cetirizine, desloratadine, fexofenadine, levocetirizine and loratadine. In overdose they cause mild CNS depression, in therapeutic and supra therapeutic doses they have been associated with QT prolongation.

Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.

Which non-sedating antihistamine should I prescribe? For most adults, cetirizine, loratadine, and fexofenadine are usual choices as their long-term safety has been well established and their once-daily dosage may improve adherence [ Powell, 2015 ; Zuberbier et al, 2018 ; BAD, 2021 ].

Antihistamine tablets work to reduce itching which many people with kidney diseases find to be a problem, especially at night when they are trying to get to sleep.