New insights about the PDGF/PDGFR signaling pathway as a …
May 1, 2023 · PDGF-BB and PDGF-DD can trigger JAK/STAT1/3 cell signaling pathway via PDGFRβ. In 293 T and COS-7 renal cells, binding of Tyr581 and Tyr579 residues (of activated PDGFRβ) to SH2 domain (of STAT5) does not disturb …
Targeting the PDGF/PDGFR signaling pathway for cancer therapy …
Mar 31, 2022 · This review will focus on the PDGF isoforms and their binding with the related PDGFRs, the PDGF/PDGFR signaling and regulation, and especially present strategies and inhibitors developed for cancer therapy, and the related clinical benefits and side effects.
Targeting the PDGF signaling pathway in tumor treatment
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.
Platelet-derived growth factor (PDGF) signalling in cancer: rapidly ...
Platelet-derived growth factor (PDGF)-mediated signalling has emerged as one of the most extensively and deeply studied biological mechanism reported to be involved in regulation of growth and survival of different cell types.
Targeting the PDGF/PDGFR signaling pathway for cancer
Mar 31, 2022 · PDGF isoforms bind to the related PDGFRs, initiate distinct receptor dimerization and phosphorylation, provide multiple binding sites for the downstream signaling molecules, thereby activating various signaling pathways such as PI3K/AKT, MAPK/ERK, PLC-γ/DAG/PKC, JAK/STAT, and Notch pathway.
Role of platelet-derived growth factors in physiology and …
Autocrine activation of PDGF signaling pathways is involved in certain gliomas, sarcomas, and leukemias. Paracrine PDGF signaling is commonly observed in epithelial cancers, where it triggers stromal recruitment and may be involved in epithelial–mesenchymal transition, thereby affecting tumor growth, angiogenesis, invasion, and metastasis.
New insights about the PDGF/PDGFR signaling pathway as a …
By directly stimulating tumour cells in an autocrine manner or by stimulating tumour stromal cells in a paracrine manner, the platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR) pathway is crucial in the growth and spread of several cancers.
Emerging roles of PDGF-D signaling pathway in tumor …
In this review, we will summarize the results of emerging studies on the PDGF-D signaling pathway, including the upstream regulators and the downstream effectors of the PDGF-D pathway, as well as its implication in human cancers.
Platelet-derived Growth Factor (PDGF) Signaling Pathway
Platelet-derived growth factor receptor (PDGFR) signaling plays a crucial role in specifying mesenchymal stem cell (MSC) commitment to mesenchymal lineages. Platelet-derived growth factor signaling critically regulates postinfarction repair. Both PDGFR-β– and PDGFR-α–mediated pathways promote collagen deposition in the infarct.
PDGF Pathways and Growth of Basal Cell and Squamous Cell …
PDGF signaling is involved in embryogenesis, carcinogenesis, atherosclerosis and wound healing. 2-5 During cancinogenesis, PDGF receptor is frequently activated through over-expression of the ligand and its receptor. PDGF belongs to PDGF/VEGF family with several conserved cysteine residues.
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