Quinazoline is an organic compound with the formula C 8 H 6 N 2. It is an aromatic heterocycle with a bicyclic structure consisting of two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow crystalline solid that is soluble in water.

Quinazolines are nitrogen-containing heterocycles that consist of a benzene ring fused with a pyrimidine ring. Quinazolinones, oxidized quinazolines, are promising compounds with a wide range of biological activities.

May 10, 2018 · This review gives detailed attention on in vitro and in vivo pharmacological activities of quinazoline and its analogs in the perspective of drug discovery and its development.

Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities ...

May 10, 2018 · Quinazoline (1,3-diazanaphthalene) is a nitrogen containing heterocyclic compound illustrated by a double-ring structure that contains a benzene ring system fused to pyrimidine at two adjacent carbon atoms (Fig. 1).

Quinazoline (1,3-diazanaphthalene; 1) is a moiety made up of two condensed six-membered aromatic rings, a pyrimidine ring, and a benzene ring (Wang and Gao, 2013). It is yellow and amorphous, and its molar mass is 130.15 g.mol −1, and the chemical formula is C 8 H 6 N 2.

Quinazoline is a mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms. It is a mancude organic heterobicyclic parent, a member of quinazolines, an azaarene and an ortho-fused heteroarene.

Quinazoline is a bicyclic heterocycle with benzene ring fused with pyrimidine nucleus. Quinazoline has contributed to many pharmacological profiles such as anti-cancer, anti inflammatory [58], anti-tubercular [59], antibacterial [60], anti leishmanial agents [61].

Dec 2, 2022 · The developing understanding of quinazoline derivatives and their biological targets presents opportunities for the discovery of novel therapeutics. This review represents different aspects of medicinal chemistry, including drug design, structure–activity relationship, and the mode of action of some analgesic and anti-inflammatory quinazoline ...

Proposed anticancer mechanisms for quinazoline derivatives include: 1) inhibition of the DNA repair enzyme system, 2) inhibition of EGFR, 3) thymidylate enzyme inhibition and 4) inhibitory effects for tubulin polymerize.