The main types of RNA therapeutics are those based on messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), and RNA aptamers. Of the four types, mRNA-based …

2022年7月23日 · A defined sequence of RNA drugs makes the design of RNA therapeutics much easier. Multiple RNA drugs are approved and a dozen more are in phase III trials to treat rare …

This comprehensive review presents pharmacology of both RNA drugs and RNA-targeted small-molecule medications, focusing on novel mechanisms of action, the most recent progress, and …

2022年4月19日 · RNA therapy refers to the treatment or prevention of diseases using RNA-based molecules. The recent advent of a series of effective messenger RNA-based vaccines in …

After summarizing the promise of RNA drugs, we review specific types of RNA drugs and their novel mechanisms of action and discuss major barriers in the development of RNA …

RNA therapy has many advantages over existing small molecule or monoclonal antibody-based therapies, including its potential to target all genes in the cells. This review will introduce the …

RNA therapy is a term used to describe the use of RNA-based molecules to modulate biological pathways to cure a specific condition. In general, the RNA sequence is the key to manipulating …

RNA-targeting small molecules represent a class of small molecules, organic compounds with traditional drug properties (e.g., Lipinski's rule of five) that can bind to RNA secondary or …

2022年1月4日 · RNA-based gene therapy requires therapeutic RNA to function inside target cells without eliciting unwanted immune responses. RNA can be ferried into cells using non-viral …

2 天之前 · RNA-Seq is utilised throughout different stages of drug discovery and development to study the transcriptome—the complete set of RNA molecules in a cell—and to elucidate …