T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface. T cells are born from hematopoietic stem cells, [1] found in the bone marrow.

2022年2月1日 · Current COVID-19 vaccines elicit robust T cell responses that likely contribute to remarkable protection against hospitalization or death, and novel or heterologous regimens offer the potential...

To provide a comprehensive overview, this review will summarize the T cell response broken down into three major stages: activation, differentiation, and memory formation. We will then assemble these components into a description of the anatomy of an immune response and its relationship to productive immune protection. T Cell Activation

The T-cell response is a key component of the adaptive immune response to viral infection. 68 CD8 + T cells are important because of their specific cytotoxicity for infected cells, while CD4+ T cells are important because they activate CD8 + cells and B cells and also produce cytokines that favor cell recruitment.

2023年6月19日 · In response to acute and chronic infections and tumors, T cells adopt distinct differentiation trajectories and develop into a range of heterogeneous populations with various phenotype,...

The activation of naive T cells in response to antigen, and their subsequent proliferation and differentiation, constitutes a primary immune response. At the same time as providing armed effector T cells, this response generates immunological memory, which gives protection from subsequent challenge by the same pathogen. The generation of memory ...

It has been demonstrated that immunization with BNT162b2 or Ad26.COV2.S can induce widespread T-cell-mediated immune responses (including both CD4+ and CD8+) against VOCs, such as the Omicron variant. These T-cell responses are also long-lasting and can persist more than eight months after immunization . Other research examined the efficiency ...

2024年6月20日 · A strong T-helper response helps control viral replication and spread by activating cytotoxic T cells and facilitating the production of antibodies. Additionally, an effective T-helper response might help mitigate disease progression by promoting the clearance of infected cells and reducing the severity of symptoms.

Infection or vaccination induces multi-epitope CD4 and CD8 T cell responses with polyfunctionality. Early T cell responses have been associated with mild COVID-19 outcomes. In concert with animal model data, these results suggest that while antibody responses are key to prevent infection, T cell responses may also play valuable roles in ...

2024年5月22日 · Following symptomatic BTI, we observed (1) enhanced S-specific CD4 and CD8 T cell responses in donors without previous asymptomatic infection, (2) expansion of CD4 and CD8 T cell responses to non-S targets (M, N, and nsps) independent of SARS2 variant, and (3) generation of novel epitopes recognizing variant-specific mutations.