Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. [5] [6] The TCF7L2 gene is located on chromosome 10q25.2–q25.3, contains 19 exons.

2024年12月25日 · TCF7L2 (Transcription Factor 7 Like 2) is a Protein Coding gene. Diseases associated with TCF7L2 include Type 2 Diabetes Mellitus and Autism. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

TCF7L2 regulates adipocyte size, adipocyte endocrine function, and glucose metabolism. TCF7L2 expression in white adipose tissue is suppressed in genetic and high fat diet–induced models of obesity.

TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway.

TCF7L2, the susceptibility gene with the largest effect on disease susceptibility discovered to date, was identified pre–genome-wide association by Grant et al. in 2006, with rapid replication of its consequence on diabetes susceptibility in multiple populations (5–9).

TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR. TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes. Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy.

TCF7L2 is a transcriptional regulator of the canonical Wnt‐signaling pathway, a major transducer of β‐catenin activity. It also regulates cell fate specification during development and cell proliferation (Clevers, 2006; Köttgen et al., 2008; MacDonald et al., 2009; Peifer & Polakis, 2000).

TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway.

2009年11月23日 · The TCF7L2 variant rs7903146 appears to affect risk of type 2 diabetes, at least in part, by modifying the effect of incretins on insulin secretion. This is not due to reduced secretion of GLP-1 and GIP but rather due to the effect …

2006年7月20日 · Common polymorphisms of the transcription factor 7–like 2 gene (TCF7L2) have recently been associated with type 2 diabetes. We examined whether the two most strongly associated variants ...