The Cyclic AMP Pathway - PMC - PubMed Central (PMC)
cAMP was the first second messenger to be identified. Its three main effectors are PKA (which phosphorylates numerous metabolic enzymes), EPAC (a guanine-nucleotide-exchange factor), and cyclic-nucleotide-gated ion channels.
Biochemistry, cAMP - StatPearls - NCBI Bookshelf
2023年7月25日 · In the heart, cAMP exerts a vital role in regulating myocardial contraction and relaxation. cAMP, produced from beta-adrenergic stimulation, activates PKA and induces a positive inotropic effect on the heart by coupling with the phosphorylation of L-type Calcium channels and ryanodine receptors.
The cAMP Signal Transduction Pathway | Science Signaling - AAAS
2010年4月27日 · AC produces cAMP, which binds the regulatory subunits of protein kinase A (PKA), allowing release and activation of the catalytic subunits of PKA. These subunits then phosphorylate downstream substrates such as troponin I and glycogen phosphorylase kinase.
Complex roles of cAMP–PKA–CREB signaling in cancer
2020年11月24日 · Aberrant cAMP–PKA signaling is involved in various types of human tumors. Especially, cAMP signaling may have both tumor-suppressive and tumor-promoting roles depending on the tumor types and context. cAMP–PKA signaling can regulate cancer cell growth, migration, invasion and metabolism.
The cyclic AMP signaling pathway: Exploring targets for …
2022年3月6日 · Adenylate cyclase (AC) converts adenosine triphosphate (ATP) into cAMP, which stimulates cAMP-dependent protein kinase A (PKA). Subsequently, specific proteins are phosphorylated by PKA (2) to evoke cellular reactions.
Mitochondrial cAMP-PKA signaling: What do we really know?
2018年9月1日 · The cAMP-PKA signaling emerged in recent years as a direct and powerful mean to regulate mitochondrial functions. Multiple evidence demonstrates that such pathway can be triggered from cytosol or directly within mitochondria.
Molecule of the Month: cAMP-dependent Protein Kinase (PKA)
PKA delivers cellular signals by adding phosphates to proteins. Inactive (top) and active (bottom) forms of cAMP-dependent protein kinase. Flexible portions of the protein are shown schematically with dots.
epinephrine takes place. The cyclic-AMP (cAMP) cascade begins with the production of cAMP, which is a pure signaling molecule, i.e., not a metabolism intermediate. cAMP binds and activates protein kinase A (PKA). PKA converts phosphorylase-b into phosphorylase-a, which is phosphorylated and active, in two steps. PKA converts glycogen
The cAMP/Protein Kinase A Pathway Regulates Virulence and …
2019年6月18日 · In this review, we focus first on insights into the role of the cAMP/PKA pathway in nutrient sensing for the model yeast Saccharomyces cerevisiae to provide a foundation for understanding the pathway in C. neoformans.
Promoting proteostasis by cAMP/PKA and cGMP/PKG - Cell Press
2024年10月29日 · Proteasome activation by cAMP/protein kinase (PK)-A and/or cGMP/PKG enhances ubiquitin–proteasome system (UPS)-mediated degradation of pathogenic proteins and protects against neural and heart diseases with increased proteotoxic stress (IPTS). Ser14-phsphorylated RPN6 is the primary mediator of 26S proteasome activation by PKA.
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