Pathology Outlines - CD3
Mar 18, 2022 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) and are required for TCR cell surface expression and signal transduction (Immunity 2006;24:133, Nature 2019;573:546)
Pathology Outlines - CD1-9
Jan 20, 2025 · Uses by pathologists: T cell marker (membranous staining), although CD3 is more commonly used; marker of systemic mastocytosis Positive staining - normal: Thymocytes (95%), mature peripheral T cells (almost all), NK cells (80 - 90%), mast cells Variable thymic B cells (50%), Langerhans cells Positive staining - disease:
Pathology Outlines - CD38
May 18, 2023 · Several other anti-CD38 antibodies, including bispecific anti-CD3 / CD38 antibodies, are in development or have recently been approved for treatment in multiple myeloma (e.g., isatuximab, approved March 2020) (Front Immunol 2018;9:2722, Front …
Pathology Outlines - CD68
Jul 5, 2022 · Areas of tumoral necrosis are present. Immunohistochemical stains show that the atypical infiltrate are positive for CD4, CD33, CD43, CD68 (KP1) and CD68 (PGM1). The atypical cells are negative for CD3, CD20, PAX 5, CD34, CD56, CD123 and muramidase. A Ki67 stain is positive in 90% of tumor cell nuclei.
Pathology Outlines - Flow cytometry
Jul 11, 2023 · T cell markers: CD2, CD3, CD4, CD5, CD7, CD8 NK cell markers: CD2, CD3, CD56 Plasma cell markers: CD38, CD138, CD56 Fine needle aspiration of lymph node with flow cytometry Rapid onsite evaluation Material processed for Routine smears Cell block Flow cytometry Cytogenetics
Pathology Outlines - WHO 2022 & ICC-T / NK cell
Jul 19, 2023 · 2 new classification systems for T / NK cell lymphoid neoplasms emerged in 2022 and evolved from the previous WHO revised 4th edition of 2016 (WHO HAEM4R)
Pathology Outlines - CD Markers - General
Jun 24, 2021 · CD: cluster designation or cluster of differentiation; a protocol to identify and investigate cell surface molecules
Pathology Outlines - CD45 (LCA)
Feb 1, 2022 · Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). CD45 is positive in nearly all cases and it is an important marker together with other B cell markers (CD20, PAX5, CD19, CD79a, CD75, OCT2 and BOB1) in differentiating classic Hodgkin lymphoma (CHL) …
Pathology Outlines - CD5
CD5 is a pan-T cell marker belonging to the scavenger receptor cysteine rich (SRCR) superfamily of receptors (Eur J Immunol 2016;46:1490) Used for diagnosis of lymphomas and thymic carcinoma Helps differentiate chronic lymphocytic leukemia (CLL) and mantle cell lymphoma from other types of low grade B cell non-Hodgkin lymphomas
Pathology Outlines - CD8
Aug 24, 2023 · Marker of T cells (normal and malignant) Marker of cytotoxic / suppressor T cells Classify lymphomas Differentiate splenic hamartoma (CD8+) from hemangioma or littoral cell angioma (CD8-) Note: use of CD3, CD8 does NOT improve detection of gluten-sensitive enteropathy in duodenal biopsies (Mod Pathol 2013 Apr 5 [Epub ahead of print])