More from Immunity - Cell Press
We welcome studies that provide fundamental new immunological insights at the molecular, cellular, or whole organism level that are relevant, but not limited, to cancer, infectious disease, the nervous system, autoimmunity, allergy, mucosal immunity, and homeostasis.
Hypoxia-inducible factor 2α promotes pathogenic ... - Cell Press
2024年11月27日 · T helper 2 (Th2) cells orchestrate immunity against parasite infection and promote tissue repair but promote pathology in asthma and tissue fibrosis. Here, we examined the mechanisms driving pathogenic differentiation of Th2 cells.
Sialylated IgG induces the transcription factor REST in ... - Cell Press
2024年11月13日 · Notably, treatment of cells with sialylated IgG prior to the inflammatory stimulus rendered their transcriptomes indistinguishable from cells that were stimulated with asialylated IgGs only, demonstrating a complete blunting of the inflammatory response by the presence of sialylated IgG (Figure S6F).
Phase separation of chimeric antigen receptor promotes …
CAR-T cells form disorganized immunological synapses. Xu et al. find that incorporation of the CD3ε module into CAR induces liquid-liquid phase separation, promoting the formation of mature immunological synapse with integrated antigen and costimulatory signaling.
Targeting the aminopeptidase ERAP enhances antitumor immunity …
2024年11月18日 · MHC class I interactions with different immune receptors can mediate either activating or inhibitory functions. Tsao, Anderson, Finn, et al. show that loss of ERAP, the aminopeptidase that trims peptides for presentation on MHC class I, enhances immune cell cytotoxicity and the response to immune checkpoint blockade.
Maintenance and functional regulation of immune memory to
2024年11月6日 · While vaccine-induced immunity circulates through blood, Davis-Porada et al. reveal that T and B cell memory generated by COVID-19 mRNA vaccines is stably maintained across lymphoid and mucosal tissues.
Microbes and metabolites in immunity - Cell Press
2024年9月10日 · The impact of the gut microbiome on immune cell training, translocation, and metabolite availability is becoming increasingly clear in diverse cancer contexts.
Interleukin-1α release during necrotic-like cell death generates ...
2024年12月9日 · Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer
The conceptual foundations of innate immunity: Taking ... - Cell Press
2024年4月9日 · Innate immunity is diverse and highly complex, with intricate crosstalk between its various levels and mechanisms, as illustrated, for instance, by the multilevel regulation between cell-intrinsic immunity and immunity mediated by specialized cells.
SMPDL3A is a cGAMP-degrading enzyme induced by LXR ... - Cell …
2023年11月14日 · Metabolism and innate immunity are highly intertwined processes that cooperate to fulfill cellular functions in immune cells during challenges with pathogens, metabolic stimulation, and the cytokine products that they elicit. 1, 2 Cross-regulation and sharing resources exist between the metabolic pathways and innate immune pathways. However ...