CLOVES syndrome is a rare condition that is primarily characterized by congenital overgrowth of fatty tissue; malformations of the vascular system (the vessels that carry blood and lymph throughout the body); epidermal nevi; and spinal or skeletal abnormalities.

CLOVES syndrome is a rare overgrowth syndrome with complex vascular anomalies. CLOVES syndrome affects people with various symptoms, ranging from mild fatty soft-tissue tumors to vascular malformations encompassing the spine or internal organs.

Learn about CLOVES syndrome, a rare vascular anomaly that can affect a child's soft tissues, vessels, bones, skin and more from Boston Children's.

Learn about CLOVES Syndrome, including symptoms, causes, and treatments. If you or a loved one is affected by this condition, visit NORD to find resources and

CLOVES Syndrome is an overgrowth syndrome with complex vascular anomalies. CLOVES stands for Congenital, Lipomatous Overgrowth, Vascular malformations, Epidermal nevi and Scoliosis/Skeletal/Spinal anomalies.

WHAT IS CLOVES SYNDROME? CLOVES Syndrome stands for Congenital, Lipomatous, Overgrowth, Vascular Malformations, Epidermal Nevi and Spinal/Skeletal Anomalies and/or Scoliosis and was identified simultaneously and independently by Saap et al. and Alomari.

CLOVES syndrome is caused by a somatic mosaic gain-of-function mutation (a mutation that occurs after the creation of the zygote) in the PIK3CA gene [2]. It is a part of the PIK3CA -Related Overgrowth Spectrum (PROS), a group of rare overgrowth disorders [3].

A syndromic disease characterized by Congenital Lipomatous Overgrowth, progressive, complex and mixed truncal Vascular malformations, and Epidermal nevi. The Genetic and Rare Diseases Information Center (GARD) has information and resources for patients, caregivers, and families that may be helpful before and after diagnosis of this condition.

Updated 11/23/2020 – Reviewed by CLOVES Syndrome Community Scientific and Medical Advisory Board. What is CLOVES syndrome? CLOVES Syndrome is a segmental overgrowth condition with variable multisystem findings, including complex vascular anomalies.

What is CLOVES syndrome? CLOVES syndrome is a very rare disorder, one of a group of congenital (present at birth) “overgrown syndromes”, that is characterized by the presence of several problems together. CLOVES stands for: Congenital; Lipomatous; Overgrowth; Vascular; Epidermal Nevis; Spinal / Skeletal / Anomalies / Scoliosis