Resident Innate Immune Cells in the Cornea - PMC - PubMed …
The cornea is rich in innate immune cells, making it a special surface of the body. These immune cells, together with corneal cells, form a complicated network to protect against damage from hostile environments and the invasion of pathogenic microorganisms.
Mouse Corneal Immune Cell Heterogeneity Revealed by Single …
Several types of immune cells, including neutrophils, dendritic cells, macrophages, natural killer cells, T cells, and innate lymphoid cells, have been detected in the cornea using flow cytometry or immunostaining with antibodies to conventional lineage markers. 1, 3, 4 However, detailed characterization of these cells at the single-cell level ...
Resident Innate Immune Cells in the Cornea - Frontiers
2021年2月25日 · The cornea is rich in innate immune cells, making it a special surface of the body. These immune cells, together with corneal cells, form a complicated network to protect against damage from hostile environments and the invasion of pathogenic microorganisms.
Resident Innate Immune Cells in the Cornea - PubMed
2021年2月26日 · This protective effect is determined by the unique anatomical structure and cellular composition of the cornea, especially its locally resident innate immune cells, such as Langerhans cells (LCs), mast cells (MCs), macrophages, γδ T …
Redefining the human corneal immune compartment using …
The healthy human cornea is a uniquely transparent sensory tissue where immune responses are tightly controlled to preserve vision. The cornea contains immune cells that are widely presumed to be intraepithelial dendritic cells (DCs). Corneal immune cells have diverse cellular morphologies and morph …
The cornea IV immunology, infection, neovascularization, and …
Dendritic cells in the normal cornea play a crucial role in combating infections and coordinating the inflammatory arms of the immune response, particularly through coordination with T-helper cells. The role of neuropeptides is recently becoming more highlighted with different factors working on both sides of the inflammatory balance.
Corneal immune cells: Linking in vivo corneal confocal …
Purpose : In-vivo confocal microscopy (IVCM) allows non-invasive examination of corneal immune cells, but controversy exists due to morphology-based identification using this technique. This observational study aimed to (i) confirm dendritic-like cell identity in human donor corneas using immunohistochemistry (IHC) on precisely matched tissue ...
Correlation of corneal immune cell changes with clinical severity …
Our results suggest that corneal IVCM may be a powerful tool to detect early immune changes and potentially cellular inflammation of the ocular surface and could be used to complement clinical examination in DED.
Molecular Characteristics and Distribution of Adult Human Corneal ...
Our analysis identified a primary transcriptomic pattern for multiple immune cell subtypes, including naive T cells, antiviral effector CD8 + T cells, and innate immune cells such as IDO1 + mature regulatory dendritic cells (mregDCs), macrophages, monocytes, and basophils in the human corneal limbus.
Neuroimmune crosstalk in the cornea: The role of immune cells in ...
2022年11月1日 · Neuroimmune interactions can be targeted to develop immune cell-based therapeutic strategies to treat corneal neuropathy. In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with their important roles in the maintenance of nerves in both homeostasis and inflammation.