GARP-TGF-β1丨双面间谍TGF-β的下一代继任者 - 药时代DrugTimes
2022年3月16日 · GARP通过调节固有和适应性免疫系统支持TGF-β1驱动的癌细胞生长和扩散，并有利于肿瘤免疫逃避。 活性TGF-β1通过直接抑制CD8+细胞毒性T细胞（CTL）的克隆扩增和 …
肿瘤免疫抑制微环境的扳手-GARP - 知乎 - 知乎专栏
GARP在活化的 Treg细胞 上选择性表达，调控TGF-β的分泌。 TGF-β具有广泛的细胞活性。 在肿瘤内部，TGF-βs，尤其是 TGF-β1，会刺激基质细胞增生、新血管形成、癌细胞转移及抑制 …
Membrane protein GARP is a receptor for latent TGF-beta on the …
Membrane localization of latent TGF-beta mediated by binding to GARP may be necessary for the ability of Treg to activate TGF-beta upon TCR stimulation. However, it is not sufficient as …
Selective inhibition of TGF-β1 produced by GARP-expressing …
2020年9月11日 · Our results suggest that anti-GARP:TGF-β1 mAbs, by selectively blocking a single TGF-β isoform emanating from a restricted cellular source exerting tumor-promoting …
GARP regulates the bioavailability and activation of TGFβ
Glycoprotein-A repetitions predominant protein (GARP) associates with latent transforming growth factor-β (proTGFβ) on the surface of T regulatory cells and platelets; however, whether GARP …
Role of GARP in the activation of latent TGF-β1
More recently, the protein GARP was shown to be involved in TGF-β1 activation by regulatory T cells (Treg), a subset of CD4 + T lymphocytes specialized in suppression of immune …
Immunoregulatory functions and the therapeutic implications of GARP-TGF …
2018年2月20日 · GARP (glycoprotein-A repetitions predominant) is a type I transmembrane cell surface docking receptor for latent transforming growth factor-β (TGF-β) that is abundantly …
GARP: a surface molecule of regulatory T cells that is involved in …
Two anti-GARP monoclonal antibodies recognize a conformational epitope within GARP-mTGF-β complex and block the production of active TGF-β from human Tregs. The two antibodies can …
Structural basis of latent TGF-β1 presentation and activation by GARP …
2018年10月25日 · We solved the crystal structure of GARP:latent TGF-β1 bound to an antibody that stabilizes the complex and blocks release of active TGF-β1. This finding reveals how …
GARP Is Regulated by miRNAs and Controls Latent TGF-β1 …
2013年9月30日 · GARP is a transmembrane protein present on stimulated human regulatory T lymphocytes (Tregs), but not on other T lymphocytes (Th cells). It presents the latent form of …