The presence of macrophages (Mφ) in the urine of patients with glomerulonephritis (GN) reflects the pathological events in the kidney, and we have discovered the following correlations between the Mφ phenotype and the pattern of renal injury.

2022年2月22日 · Professional phagocytes like macrophages (Fig1) and neutrophils (Fig 2) are not a surprise but are still pretty neat to see in the urine sediment and can be confusing if you don’t expect them. In Fig 2, neutrophils are taking on a fungus particle much bigger than themselves!

Macrophages have broad M1 and M2 phenotype subgroups with distinctive functions and dual reno-toxic and reno-protective effects. Macrophages are a major contributor to injury in immune-complex-mediated, as well as pauci-immune, glomerulonephritis.

Figure 4D shows the representative markers of the urine macrophages: S100A8 and FCN1 were highly expressed in Groups 1 and 2, suggesting peripheral blood and bone marrow–derived macrophages. RGS1 and C1QC were highly expressed in Group 3, suggesting that they were renal resident macrophages.

2024年1月9日 · Here, using high-resolution microscopy, we found that the juxtatubular macrophages in the renal medulla constitutively formed transepithelial protrusions and “sampled” urine contents.

2024年1月9日 · This study demonstrated that a portion of macrophages are expelled in the urine after engulfing intratubular particles. However, macrophage numbers remain stable throughout life, which raised the question regarding the origin of medullary macrophages and how the kidney niche is replenished.

Macrophage polarization is a major contributing factor in acute kidney injury (AKI). We aim to determine its biomarker value in differentiating etiologic causes of various intrinsic renal AKI. A total of 205 patients with renal intrinsic AKI were enrolled.

2019年8月1日 · Macrophage polarization is a major contributing factor in acute kidney injury (AKI). We aim to determine its biomarker value in differentiating etiologic causes of various intrinsic renal AKI. A total of 205 patients with renal intrinsic AKI were enrolled.

In normal individuals mature macrophaps (25F9& cells) were ahsenl in urinary sediments. The number of 25F9' cells in the urine was highest in the highly pro- gressive group, less prominent in the moderately progressive group, and virtual1,v absent in the non-progressive group.

In normal individuals mature macrophages (25F9+ cells) were absent in urinary sediments. The number of 25F9+ cells in the urine was highest in the highly progressive group, less prominent in the moderately progressive group, and virtually absent in the non-progressive group.