Silicosis, a type of pneumoconiosis, occurs secondary to the inhalation of RCS and causes progressive, irreversible, and fatal lung inflammation and fibrosis. While the condition is preventable, no treatment exists. Silicosis increases susceptibility to Mycobacterial diseases, autoimmune diseases, and bronchogenic carcinoma. This activity ...
了解详细信息：Silicosis, a type of pneumoconiosis, occurs secondary to the inhalation of RCS and causes progressive, irreversible, and fatal lung inflammation and fibrosis. While the condition is preventable, no treatment exists. Silicosis increases susceptibility to Mycobacterial diseases, autoimmune diseases, and bronchogenic carcinoma. This activity ...
www.ncbi.nlm.nih.gov/sites/books/NBK594245/The different forms of silicosis include chronic simple, chronic complicated, accelerated, and acute silicosis, which vary by the amount and length of silica exposure. The clinical features of silicosis generally involve the development of silicotic nodules, which can coalesce to form expansive fibrotic areas known as progressive massive ...
www.atsjournals.org/doi/10.1165/rcmb.2021-0545TRSilicosis is known to produce both acute and chronic inflammation in the lung followed by progressive fibrosis. Gene set enrichment analysis revealed that inflammatory gene processes peak at d7 postexposure and chronically remain higher than baseline, while fibrotic gene expression processes continually increase following exposure (Fig. 2, C to ...
www.science.org/doi/10.1126/sciadv.adl49131. Clinical and Pathologic Features of Asbestosis and Silicosis. 2. Chemical and Physical Properties of Asbestos and Silica Important in Causation of Lung Disease. 3. The Relationship of Particle Burden to Disease in Asbestosis and Silicosis. 4. Cellular and Molecular Mechanisms of Asbestosis and Silicosis. 5. Approaches to Prevention and ...
www.atsjournals.org/doi/10.1164/ajrccm.157.5.970…" Iron Alters the Transcriptome and Volatile Organic Compounds in the BAL of Patients with Silicosis." American Journal of Respiratory Cell and Molecular Biology, 71(5), pp. 617–621
www.atsjournals.org/doi/10.1165/rcmb.2024-0181LESilicosis - StatPearls - NCBI Bookshelf
Silicosis, a type of pneumoconiosis, occurs secondary to the inhalation of RCS and causes progressive, irreversible, and fatal lung inflammation and fibrosis. While the condition is …
American Journal of Respiratory Cell and Molecular Biology
The different forms of silicosis include chronic simple, chronic complicated, accelerated, and acute silicosis, which vary by the amount and length of silica exposure. The clinical features of …
Pulmonary osteoclast-like cells in silica induced …
2024年7月10日 · Silicosis is known to produce both acute and chronic inflammation in the lung followed by progressive fibrosis. Gene set enrichment analysis revealed that inflammatory gene processes peak at d7 postexposure …
- Silicosis Biologia Molecular 的研究
American Journal of Respiratory and Critical Care Medicine
1. Clinical and Pathologic Features of Asbestosis and Silicosis. 2. Chemical and Physical Properties of Asbestos and Silica Important in Causation of Lung Disease. 3. The Relationship …
American Journal of Respiratory Cell and Molecular Biology
" Iron Alters the Transcriptome and Volatile Organic Compounds in the BAL of Patients with Silicosis." American Journal of Respiratory Cell and Molecular Biology, 71(5), pp. 617–621
Silica crystals activate toll-like receptors and inflammasomes to ...
Silica crystals are potent activators of the inflammasome that cause a fibrotic lung disease, called silicosis, with no effective treatment available. We report here that injection of silica crystals …
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In the development of silicosis, the pulmonary alveolar macrophages play a dominant role by releasing host mediators, such as chemokines and cytokines that result in the onset of
Basic pathogenetic mechanisms in silicosis: current understanding
Silicosis has been studied extensively by basic and clinical scientists, yet little is known about the crucial cellular and molecular mechanisms that initiate and propagate the process of …
Pathogenesis of silicosis: Current concepts and hypotheses
Silicosis is caused by the inhalation of crystalline silica (silicon dioxide, SiO2) in various forms. This review proposes that the cascade of inflammatory and fibrotic events involved in cell …
Animal models of silicosis: fishing for new therapeutic targets and ...
We discuss the use of zebrafish as a model of silicosis, its similarities to other animal models and the characteristics of patients at molecular and clinical levels, and show the current state of the …
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