JCI - Inhibition of aortic CX3CR1+ macrophages mitigates thoracic ...
2025年1月16日 · CX3CR1 + macrophages were greatly enriched in the intima of thoracic aortas from MFS mice and patients. The heterozygous Fbn1 C1041G/+ mice were utilized as an MFS mouse model.
Pressure overload by suprarenal aortic constriction in mice …
2020年9月18日 · Thoracic aortic constriction (TAC) is the most common PO model in mice that involves ligation of the aorta at the level of the arch and requires microsurgical...
Inhibition of aortic CX3CR1+ macrophages mitigates thoracic …
2025年1月16日 · Specific elimination of CX3CR1+ cells by diphtheria toxin in Cx3cr1-CreERT2iDTRF/+Fbn1C1041G/+ mice efficiently ameliorated TAA progression. Administering the monoclonal antibodies to respectively neutralize TNF-α and IGF1 produced by CX3CR1+ cells from MFS patients greatly suppressed the cocultured MFS patient-specific induced pluripotent ...
Mitochondrial NAD+ deficiency in vascular smooth muscle impairs ...
5 天之前 · For mouse aortic proteomic analysis, freshly frozen tissues of the thoracic aorta were isolated and then washed with PBS three times and homogenized in lysis buffer supplemented with EDTA-free ...
Structural reconstruction of mouse acute aortic dissection by ...
2024年9月9日 · Thoracic endovascular aortic repair (TEVAR), a surgical treatment intended to close the entry that connects the true lumen and false lumen, in the acute phase...
GDF11 prevents the formation of thoracic aortic dissection in mice ...
2021年3月25日 · GDF11 level was found lower in the ascending thoracic aortas of TAD patients than healthy aortas. The mouse model of TAD was established by β‐aminopropionitrile monofumarate (BAPN) combined with angiotensin II (Ang II).
Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice
2023年8月17日 · Increasing evidence has suggested a role for NE (neutrophil elastase) in vascular diseases. In this study, we aimed at investigating a causal role for NE in TAD and exploring the molecular mechanisms involved. Methods: β-aminopropionitrile monofumarate was administrated in mice to induce TAD.
Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice
2023年8月17日 · Thoracic aortic dissection (TAD) is a life-threatening aortic disease without effective medical treatment. Increasing evidence has suggested a role for NE (neutrophil elastase) in vascular diseases. In this study, we aimed at investigating a causal role for NE in TAD and exploring the molecular mechanisms involved.
miR‐133a Replacement Attenuates Thoracic Aortic Aneurysm in Mice
2021年8月8日 · Thoracic aortic aneurysms (TAAs) occur because of abnormal remodeling of aortic extracellular matrix and are accompanied by the emergence of proteolytically active myofibroblasts. The microRNA miR‐133a regulates cellular phenotypes and is reduced in clinical TAA specimens.
transporter SLC25A51 linked to human aortic disease - Nature
5 天之前 · An extensive molecular characterization of 150 human thoracic aorta specimens followed by genetic association studies and preclinical work in mice implicates the mitochondrial NAD+ transporter ...